Friday's contest that pits the San Diego Padres (75-78) against the St. Louis Cardinals (67-86) at PETCO Park has a projected final score of 6-4 (based on our computer prediction) in favor of the Padres, who is a slight favorite in this matchup according to our model. Game time is at 9:40 PM on September 22.

The probable starters are Matt Waldron (1-3) for the Padres and Dakota Hudson (6-2) for the Cardinals.

Cardinals vs. Padres Game Info & Odds

  • When: Friday, September 22, 2023 at 9:40 PM ET
  • Where: PETCO Park in San Diego, California
  • How to Watch on TV: MLB Network
  • Live Stream: Watch this game on Fubo!

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Cardinals vs. Padres Score Prediction

Our prediction for this game is Padres 6, Cardinals 4.

Total Prediction for Cardinals vs. Padres

  • Total Prediction: Over 9 runs

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Discover More About This Game

Cardinals Performance Insights

  • In nine games as the underdog over the last 10 matchups, the Cardinals have a record of 4-5.
  • When it comes to the over/under, St. Louis and its foes are 5-5-0 in its previous 10 contests.
  • Bookmakers have yet to post a spread in any of the Cardinals' past 10 games.
  • The Cardinals have been chosen as underdogs in 71 games this year and have walked away with the win 31 times (43.7%) in those games.
  • This year, St. Louis has won six of 11 games when listed as at least +145 or worse on the moneyline.
  • The moneyline set for this matchup implies the Cardinals have a 40.8% chance of walking away with the win.
  • The offense for St. Louis is the No. 18 offense in baseball, scoring 4.5 runs per game (683 total runs).
  • Cardinals pitchers have a combined ERA of 4.73 ERA this year, which ranks 23rd in MLB.

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Cardinals Schedule

Date Opponent Score Pitching Matchup
September 17 Phillies W 6-5 Dakota Hudson vs Taijuan Walker
September 18 Brewers W 1-0 Adam Wainwright vs Freddy Peralta
September 19 Brewers L 7-3 Drew Rom vs Trevor Megill
September 20 Brewers L 8-2 Zack Thompson vs Adrian Houser
September 21 Brewers L 6-0 Miles Mikolas vs Wade Miley
September 22 @ Padres - Dakota Hudson vs Matt Waldron
September 23 @ Padres - Jake Woodford vs Nick Martínez
September 24 @ Padres - Drew Rom vs Michael Wacha
September 26 @ Brewers - Zack Thompson vs Wade Miley
September 27 @ Brewers - Miles Mikolas vs Corbin Burnes
September 28 @ Brewers - Dakota Hudson vs Brandon Woodruff